SANOAT MIQYOSIDA PENITSILLIN ANTIBIOTIGINI OLISH TEXNOLOGIYASI
Kalit so‘zlar:
Penicillium rubens, Penicillium chrysogenu, antibiotik, mutagenez, fermentatsiya, sefalosporin, rentabillikAbstrak
Antibiotiklar kashf etilganidan beri penitsillin klinik tibbiyotda eng yaxshi
tanlov bo‘lib qolmoqda. Biotexnologiyaning uzluksiz rivojlanishi bilan penitsillin ishlab chiqarish
tejamkor va samarali bo‘ldi. Biosintetik yo‘llarni kuchaytirish uchun genetik muhandislik usullari
qo‘llanildi , bu esa yaxshilangan xususiyatlarga ega yangi penitsillin hosilalarini ishlab chiqarishga
va antibiotiklarga chidamli patogenlarga qarshi samaradorligini oshirishga olib keldi. Penitsillin
- bakterial infeksiyalarni davolashda keng qo‘llaniladigan birinchi antibiotik bo‘lib, uning ishlab
chiqarilishi tibbiyotda inqilob yasagan. Tezisda penitsillin olish jarayonida foydalaniladigan xom
ashyo, fermentatsiya texnologiyalari, mikroorganizmlar va ular bilan bog‘liq biotexnologik
jarayonlar haqida batafsil ma’lumot beriladi.
References
Wang, G., Chu, J., Noorman, H., Xia, J., Tang, W., Zhuang, Y., & Zhang, S. (2014). Prelude to rational scale-up of penicillin production: a scale-down study. Applied microbiology and biotechnology, 98, 2359-2369.
Sawant, A. M., & Vamkudoth, K. R. (2022). Biosynthetic process and strain improvement approaches for industrial penicillin production. Biotechnology Letters, 1-14.
Neushul, P. (1993). Science, government and the mass production of penicillin. Journal of the history of medicine and allied sciences, 48(4), 371-395.
Haque, M. A., Nath, N. D., Johnston, T. V., Haruna, S., Ahn, J., Ovissipour, R., & Ku, S. (2024). Harnessing biotechnology for penicillin production: Opportunities and environmental considerations. Science of The Total Environment, 174236.
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