Qalqonsimon bezi KASALLIKLARI PATOGENEZIDA VA DAVOLASHDA SELENIYNING O'RNI. KO'RISH.
Kalit so‘zlar:
селен, щитовидная железа, аутоиммунный тиреоидит, болезнь Грейвса, гипотиреоз, эндемический зоб, тиреоидные гормоны, антиоксидантная защита, селенопротеины, доказательная медицина.Abstrak
Sharhda selenning qalqonsimon bez kasalliklari, shu jumladan otoimmun tiroidit, Graves kasalligi, hipotiroidizm va endemik guatr patogenezi va davolashdagi roli ko'rib chiqiladi. Selen tirotsitlarni antioksidant himoya qilish va qalqonsimon gormonlar almashinuvini tartibga solishda ishtirok etadigan muhim mikroelementdir. Selenning ta'sir qilish mexanizmlari, metabolizm shakllari va otoimmün qalqonsimon bez kasalliklarini davolashda dalillarga asoslangan samaradorlik darajalari to'g'risidagi ma'lumotlar umumlashtiriladi. Dalillar darajasi (A-C) bo'yicha farqlash bilan klinik va eksperimental tadqiqotlar natijalari keltirilgan. Otoimmün tiroiditda selen antikor titrlarini kamaytirishi va klinik holatni yaxshilashi mumkinligi aniqlangan, Graves kasalligida esa uning samaradorligi munozarali bo'lib qolmoqda. Tanadagi selenning boshlang'ich darajasini hisobga olgan holda terapiyaga individual yondashuvning ahamiyati ta'kidlanadi. Endokrin amaliyotda selendan foydalanish strategiyasini optimallashtirish uchun keyingi tadqiqotlar zarurligini tasdiqlovchi xulosalar ishlab chiqilgan.
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