ENDOFIT ZAMBURUG‘LARI TOMONIDAN HOSIL QILINGAN IKKILAMCHI METABOLITLARNING E. COLI O‘SISHIGA TORMOZLOVCHI TA’SIRI
Kalit so‘zlar:
endofitlar; metabolitlar; antibakterial; rezistentlik; farmakologiya; patogenez; Escherichia coliAbstrak
- coli, tashning ortib borishi yangi antibakterial birikmalarni izlash zaruratini keskin oshirdi. Ayniqsa Gram-manfiy bakteriyalar, jumladan Escherichia coli antibiotiklarga chidamli bakteriyalar soniSo‘nggi yillarda o‘sishini tormozlashdagi biologik va tibbiy ahamiyati so‘nggi besh yillik (2020–2025) ilmiy manbalar asosida tahlil qilindi. Tahlil natijalari shuni ko‘rsatadiki, endofit zamburug‘lar sintez qiladigan poliketidlar, terpenoidlar va boshqa bioaktiv metabolitlar bakterial hujayraning bir nechta hayotiy jarayonlariga bir vaqtning o‘zida ta’sir ko‘rsatadi. Ushbu ko‘p nishonli ta’sir mexanizmi E. coliga xos rezistentlik mexanizmlarini qisman chetlab o‘tish imkonini beradi. Shuningdek, endofit metabolitlarining membrana permeabilitetini oshirishi, fermentativ faoliyatni susaytirishi va oksidlovchi stressni kuchaytirishi antibakterial samaradorlikning asosiy omillari sifatida baholanadi. Maqolada endofit zamburug‘ metabolitlarining mustaqil antibiotik sifatida emas, balki kombinatsiyalangan antibakterial terapiyada istiqbolli komponent ekanligi asoslab beriladi.
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