STUDY OF RS2243250 POLYMORPHISM OF IL-4 GENE IN CASES OF HABITUAL LOSS OF PREGNANCY IN UZBEKISTAN
Keywords:
невынашивание беременности, IL-4, полиморфизм, Real-Time ПЦР.Abstract
Recurrent pregnancy loss (RPL) remains one of the pressing problems in reproductive medicine. According to current data, about 1–2% of women of reproductive age suffer from recurrent miscarriages, and in a significant number of cases, the cause remains unclear [1]. Among the many factors influencing the development of RPL, special attention is paid to immunological and genetic aspects [2]. Anti-inflammatory cytokines such as IL-10, TGF-β1, and IL-4 play an important role in maintaining the immune balance during pregnancy. IL-4 promotes the formation of a Th2 response and suppression of Th1 cells associated with inflammation [3]. Genetic variations affecting the expression of these cytokines may increase the risk of miscarriage.
References
Алегина Е.В., Тетруашвили Н.К., Агаджанова А.А., Трофимов Д.Ю., ДонниковА.Е. Генный полиморфизм как фактор, предрасполагающий к привычным потерямбеременности. Акушерство и гинекология. 2014;(4):48–54.
Гордеева Л.А., Оскорбина О.С., Воронина Е.Н. и др. Ассоциации полиморфизмагенов цитокинов с невынашиванием беременности. Медицинская иммунология.2017;19(5):585–596.
The role of cytokines IL-6 and IL-8 in the pathogenesis of spontaneous abortionsG Galazios, S Tsoulou, C Zografou, G Tripsianis
Tsechoeva T.K., Dzhanayeva M.Kh., Kulova Z.Kh., Tlekhuray I.D. Genetic factors ofspontaneous abortion. Russian Medical Journal. 2021;29(3):45–50.
Polymorphisms of IL-1β, IL-4, IL-17A, IL-12B, and TNFα genes in reproductive loss.Medical Immunology. 2019;21(2):123–130.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Махмудова М, Капралова Ю.А., Абдурахимов А.А, Абдуллаев А.А, Якубов И.Т
This work is licensed under a Creative Commons Attribution 4.0 International License.
(+998)90 142-39-38
m.z.abdutolibov@gmail.com
@universal_jurnal
House 189 Kashgar Street, Marhamat district, Andijan region