DISORDERS OF FAT DIGESTION IN CHRONIC HEPATITIS AND CHOLISTIS.

Abstract

Liver (hepatitis) and gallbladder (cholecystitis) diseases are the central disruption of fat metabolism in the human body. This article provides an in-depth analysis of the pathophysiological mechanisms of impaired digestion and absorption of fats in chronic hepatitis and cholecystitis. Chronic hepatitis directly affects hepatocytes by damaging them and reducing their ability to synthesize bile acids. Cholecystitis, on the other hand, makes it difficult for bile to be delivered to the small intestine in a timely and sufficient amount due to inflammation and dyskinesia of the gallbladder. As a result, lipase activation is impaired, fat emulsification is reduced, which clinically leads to such syndromes as steatorrhea (fat in the feces) and deficiency of fat-soluble vitamins (A, D, E, K). Understanding the consequences of these metabolic disturbances is crucial for developing dietary and pharmacological support strategies for patients with chronic liver and biliary tract diseases.