STEROID GORMONLAR SINTEZI VA KATABOLIZMI
Kalit so‘zlar:
Steroidogenez, xolesterin, P450scc (CYP11A1), StAR, HPA aks sikli, faza I va faza II metabolizm, UGT2B17, SULT1E1Abstrak
UshSteroid gormonlar xolesterindan sintezlanib, organizmda muhim
fiziologik funktsiyalarni – suyuqlik-elektrolit muvozanatini, immun javobni, stressga
moslashuvni, reproduktiv jarayonlarni va metabolizmni boshqaradi. Ularning sintezi
mitoxondriyalarda P450scc (CYP11A1) fermenti yordamida xolesterin →pregnenolon aylanishi
bilan boshlanib, sitoxrom P450 fermentlari (CYP17A1, CYP21A2, CYP11B1, CYP11B2,
CYP19A1) va gidroksisteroid dehidrogenazalar (3β-HSD, 17β-HSD) orqali kortizol, aldosteron,
testosteron va estradiol sinteziga olib keladi.
References
Steroid biosintezi va metabolizmi. Wikipedia. en.wikipedia
Sitoxrom P450 fermentlari steroidogenezda. Wikipedia. en.wikipedia
Steroidogenic acute regulatory protein (StAR). Wikipedia. en.wikipedia
Gipotalamus–gipofiz–ustuvbez aks sikli (HPA). Wikipedia. en.wikipedia
Gipotalamus–gipofiz–gonadalar aks sikli (HPG). Wikipedia. en.wikipedia
Steroid katabolizmi va chiqarilishi. Wikipedia.
UGT2B17. Wikipedia. en.wikipedia
Steroid sulfotransferaza (SULT). Wikipedia. en.wikipedia
Schiffer L. et al. Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review. J Steroid Biochem Mol Biol. 2019;194:105439. pmc.ncbi.nlm.nih
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