ERTA HOMILADORLIK BOSQICHIDA AYOLLAR IMMUN TIZIMI KO‘RSATKICHLARI VA PROTEAZA INGIBITORLARINING DINAMIKASI
Kalit so‘zlar:
interleykinlar, erta homiladorlik, abortAbstrak
Tadqiqοtda homiladorlikning 12 haftasigacha bo'lgan dastlabki bosqichlarda infektsiyasiz va genital infektsiyasi bo'lgan ayollarda immunologik parametrlar va proteaz inhibitorlarini o'zgarishi o'rganildi. Erta homiladorlik davrida sezilarli yallig'lanish oldi immunitetning yo'qligi, proteaza inhibitorlarining etarli darajada tuzatuvchi reaktsiyasi va TGF-β1 yuqumli omillarning mavjudligida ham erta homiladorlikning qulay kechishiga va to'liq homiladorlikning rivojlanishiga yordam berishi mumkin degan xulosaga kelindi. Shuning uchun yallig'lanish oldi (TNF-α, IL-1β) va yallig'lanishga qarshi interleykinlar (IL-10), shuningdek proteaza inhibitorlari (α-1-anti-tripsin) va TGF-β1 tadqiqotlari homiladorlikning dastlabki davrida immunitet tizimining etarliligi va marker sifatida ishlatilishi mumkin.
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