VINKANIN VA PIRAZOLIN INDOL ALKALOIDLARINING KARDIOPROTEKTOR TA’SIR

Mualliflar

  • Jumayev I.Z.
    O‘zMU huzuridagi Biofizika va biokimyo instituti
  • Boboyev S.N.
    O‘zMU huzuridagi Biofizika va biokimyo instituti
  • Qurbonova SH.N
    O‘zMU huzuridagi Biofizika va biokimyo instituti
  • Usmanov P.B.
    O‘zMU huzuridagi Biofizika va biokimyo instituti
  • Adizov SH.M.
    O‘zR FA O‘simlik moddalar kimyosi instituti

Annotasiya

Yuqorida olib borilgan tadqiqotlar tahliliga ko‘ra, vinkanin va pirozalin
alkaloidlari kuchli kardiprotektor xususiyatga ega bo‘lib, gipoksiya natijasida yuzaga kelgan
papillyar muskul qisqarish faolligidagi buzilishlarni samarali bartaraf etadi. O‘rganilayotgan
alkaloidlarning ushbu funksiyasi asosan kardiomiotsitlarda [Sa2+]in dinamikasi
modulyatsiyasiga bog‘liqligini taxmin qilish imkonini beradi.

Kalit so‘zlar:

Yurak muskul gomeostazini oq zotsiz

Bibliografik manbalar

Guillaume Gilbert, Kateryna Demydenko, Eef Dries, Rosa Doñate Puertas, Xin Jin, Karin Sipido, and H. Llewelyn Roderick. Calcium Signaling in Cardiomyocyte Function // Cold Spring Harb Perspect Biol. 2020 Mar; 12(3): a035428.

Min Luo and Mark E. Anderson. Ca2+ Cycling in Heart Failure // Circ Res. 2013 Aug 30; 113(6): 690–708.

Inoyat Z. Zhumaev, Sadriddin N. Boboev, Pulat B. Usmanov, Shakhnoza B. Qurbonova, Shavkat Yu. Rustamov, Adilbay T. Esimbetov, Gulnaz S. Begdullaeva, Abdisalim A. Zaripov and Shahobiddin M. Adizov. Mechanism of Positive Inotropic Effect of Vincanine on Cardiac Muscle Contraction Activity // Biomedical & Pharmacology Journal, December 2022. Vol. 15(4), p. 2309-2316

Parpiyeva, M., Tuychiyeva, D., & Numonjonov, M. (2020). EFFECTS OF HALOXYFOP-R-METHYLE AND INDOXACARB PESTICIDES ON THE STRUCTURE OF THE INTERNAL ORGANS OF RATS. Norwegian Journal of Development of the International Science, (45-2), 15-17.

Paridakhon, M., Dilfuza, T., Mashkhura, P., Dilnoza, B., & Ra’no, A. (2020). Some Indicators of Blood of Rats Poisoned with Pesticide Karate. International Journal of Multicultural and multireligious understanding, 7(7), 546-557.

Parpieva, M., Mirkhamidova, P., Pozilov, M., & Alimova, R. (2023). Effects of sophoroflavonoside and narcissin flavonoids on mitochondrial dysfunction and antioxidant enzyme activity in rat liver poisoned with galoxyfop-r-methyl pesticide. In E3S Web of Conferences (Vol. 421, p. 04008). EDP Sciences.

Туйчиева, Д., Муминова, Г., & Парпиева, М. (2018). Действие пестицидов на фосфолипидный состав митохондрий печени беременных крыс и их эмбрионов. Научный альманах, (3-2), 207-210.

Mashkhura, P., & Parida, M. (2020). Determination of residual pesticide in the liver of rats poisoned with indoxacarb pesticide. European Journal of Molecular and Clinical Medicine, 7(3), 4447-4505.

Туйчиева, Д., Мирхамидова, П., Бабаханова, Д., Парпиева, М., & Алимова, Р. (2020). ВЛИЯНИЕ ПЕСТИЦИДОВ НА АКТИВНОСТЬ НЕКОТОРЫХ ФЕРМЕНТОВ ПЕЧЕНИ КРЫС И ПУТИ ИХ КОРРЕКЦИИ. Norwegian Journal of Development of the International Science, (45-2), 8-14.

Parpieva, M. Z., & Tujchieva, D. S. (2021). Jigar, uning inson organizmidagi vazifalari va ahamiyati. Молодой ученый, (10), 234-237.

Dilfuza, T., Mashhura, P., Parida, M., Dilnoza, B., & Rano, A. (2020). Effect of pesticides on the content of cytochrome P-450 of the monooxygenase system and on the ultrastructure of hepatocytes in rat embryos. European Journal of Molecular and Clinical Medicine, 7(3), 2473-2483.

Mirkhamidova, P., Bobokhonova, D., Tuychieva, D., & Parpieva, M. (2020). Influence of karate on the activity of enzymes of the anti-oxidizing system of rat liver protection and ways of their correction. European Journal of Molecular and Clinical Medicine, 7(3), 3757-3765.

Parida, M., Komiljonovich, P. M. M., Javdatovna, P. M., Abdullaevna, S. G., & Abjapparovna, J. K. (2022). Determination of the amount of residual pesticides in the liver tissue of rats poisoning with haloxyphop-r-methyl and indosacarb pesticides. Journal of Pharmaceutical Negative Results, 738-745.

Yuklashlar

Nashr qilingan

Qanday qilib iqtibos keltirish kerak

Jumayev I.Z., J. I., Boboyev S.N., B. S., Qurbonova SH.N, Q. S., Usmanov P.B., U. P., & Adizov SH.M., A. S. (2024). VINKANIN VA PIRAZOLIN INDOL ALKALOIDLARINING KARDIOPROTEKTOR TA’SIR. Universal Xalqaro Ilmiy Jurnal, 1(4), 105–106. Retrieved from https://universaljurnal.uz/index.php/jurnal/article/view/462

Nashr

Jild 1 № 4 : “Odam fiziologiyasi va hayot faoliyati xavfsizligi fanlarining dolzarb muammolari, innovatsiya va istiqbollari” mavzusidagi Respublika ilmiy-amaliy anjumani materiallari

Bo'lim

Maqolalar

Litsenziya

Mualliflik huquqi (c) 2024 Jumayev I.Z., Boboyev S.N., Qurbonova SH.N, Usmanov P.B., Adizov SH.M.

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