ROMASHKA EKSTRAKTINI KALAMUSH AORTA SILLIQ MUSKULLARI Na+ /Ca2+ ALMASHINUVIGA TA’SIRINI O‘RGANISH
Kalit so‘zlar:
kaliy, Aorta halqalari, fiziologik eritmaAbstrak
Adabiyotlardan ma’lumki, Na+
/K+
-ATFaza -hayvon to‘qimalari
hujayra membranasining fermenti bo‘lib, ATF energiyasidan foydalangan holatda, hujayradan
natriy ionlarini tanlab chiqarib yuborish va kaliy ionlarini hujayra ichiga yig‘ish vazifasini
bajaradi. Adabiyotlardan ma’lumki, oaubain Na+
/K+
-AFTaza strukturasida uning faolligini
susaytiruvchi α-subbirlik bilan bog‘lanish xosil qiladi va qon tomir silliq muskul hujayralari
ichida [Na+]in konsentratsiyasi ortishi orqali Na+
/Ca
2+
-almashuv tizimi reversion funksiyasi
asosida [Ca
2+ ]in ko‘payishi qisqarish kuchi ortishini keltirib chiqaradi.
References
Edwards G., Thollon C., Gardener M.J., Feletou M., Vilaine J., VanHoutte P.M., Weston A.H. Role of gap junctions and EETs in endothelium-dependent hyperpolarization of porcine coronary artery // Br. J. Pharmacol. –2000. –V. 129. –P. 1145-1154.
Edwards G., Dora K.A., Gardener M.J., Garland C.J., Weston A. K+ is an endothelium-derived hyperpolarizing factor in rat arteries // Nature. –1998. –V. 96. –P. 269-272.
Eggermont J.Calcium-activated chloride сchannels // The Proceedings of the American Thoracic Society. –2004. –V. 1. –P. 22-27.
Ertl P, Rohde B, Selzer P. Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties. J Med Chem. 2000; 43(20):3714–7.
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