ANTIBIOFILM ACTIVITY OF PENICILLIUM ROQUEFORTI 12PH -ENDOPHYTIC FUNGUS OF PEGANUM HARMALA

Abstract

Today it is clear that when an insufficient concentration of antibiotic is introduced
into the body for the co1.5mplete elimination of the pathogen, a certain part of the pathogen
survives and becomes resistant to the antibiotic used [1, p. 2]. After the formation of biofilm by
pathogenic microorganisms on the internal surfaces of the human or animal body, their resistance
to various drugs and antibiotics increases up to 1000 times [2, pp. 149–161], which in turn
negatively affects the effectiveness of the drugs used. At the same time, the combined use of
substances that destroy and prevent the formation of biofilm increases the effectiveness of the
applied methods of therapy. In connection with the above, the purpose of our study was to study
the effect of the total extract of the Penicillium roqueforti 12Ph strain on the formation of
pathogenic biofilm and the decomposing effect on the formed biofilm.