PENICILLIUM ROQUEFORTI 12PH - PEGANUM HARMALANI ENDOFITIK QO'RG'OSI ANTIBIOFILM FAOLIYATI

Mualliflar

  • Yusupov Ulugbek Kokand Universiteti Andijon filiali
  • Xaitboyeva Esidora Kokand Universiteti Andijon filiali
  • Abdulmyanova Liliya Kokand Universiteti Andijon filiali

Abstrak

Bugungi kunda antibiotikning etarli kontsentratsiyasi kiritilganda aniq bo'ladi
patogenni, patogenning ma'lum qismini CO1,5 m.lik yo'q qilish uchun organizmga
omon qoladi va ishlatiladigan antibiotikga chidamli bo'ladi [1, p. 2]. tomonidan biofilm hosil bo'lgandan keyin
inson yoki hayvon tanasining ichki yuzalarida patogen mikroorganizmlar, ularning qarshiligi
turli dori-darmonlar va antibiotiklarga nisbatan 1000 martagacha oshadi [2, 149-161-betlar], bu esa o'z navbatida.
qo'llaniladigan dorilarning samaradorligiga salbiy ta'sir qiladi. Shu bilan birga, birgalikda foydalanish
biofilm hosil bo'lishini yo'q qiladigan va oldini oladigan moddalar samaradorligini oshiradi
qo'llaniladigan terapiya usullari. Yuqoridagilar bilan bog'liq holda, bizning tadqiqotimizdan maqsad o'rganish edi
Penicillium roqueforti 12Ph shtammining umumiy ekstraktining hosil bo'lishiga ta'siri.
patogen biofilm va hosil bo'lgan biofilmga parchalanish ta'siri.

References

“The Minimum Inhibitory Concentration of Antibiotics: Methods, Interpretation, Clinical Relevance.”

T. B. Rasmussen and M. Givskov, “Quorum-sensing inhibitors as anti-pathogenic drugs,” Int J Med Microbiol, vol. 296, no. 2–3, pp. 149–161, Apr. 2006, doi: 10.1016/j.ijmm.2006.02.005.

N. Kaur, D. S. Arora, N. Kalia, and M. Kaur, “Antibiofilm, antiproliferative, antioxidant and antimutagenic activities of an endophytic fungus Aspergillus fumigatus fromMoringa oleifera,” Mol Biol Rep, vol. 47, no. 4, pp. 2901–2911, Apr. 2020, doi: 10.1007/s11033-020-05394-7.

P. S. Stewart et al., “Effect of Catalase on H ydrogen Peroxide Penetration into Pseudomonas aeruginosa Biofilms,” Appl Environ Microbiol, vol. 66, no. 2, pp. 836–838, Feb. 2000.

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Jild 2 Nomeri 4.5 (2025): FARMASEVTIKA, BIOTEXNOLOGIYA VA BIOTIBBIYOTDA ZAMONAVIY TADQIQOTLAR VA ILMIY YANGILIKLAR” mavzusidagi xalqaro ilmiy-amaliy konferensiya Andijon. 23-24 aprel 2025-yil

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PENICILLIUM ROQUEFORTI 12PH - PEGANUM HARMALANI ENDOFITIK QO’RG’OSI ANTIBIOFILM FAOLIYATI. (2025). Universal Xalqaro Ilmiy Jurnal, 2(4.5), 17-19. https://universaljurnal.uz/index.php/jurnal/article/view/2281