MECHANISMS OF CONTRACTION AND RELAXATION OF AORTIC SMOOTH MUSCLE CELLS
Keywords:
aorta, silliq tolali muskul hujayralari, tunica media, Ca²⁺/kalmudulin/MLCK, RhoA/ROCK, PKC/CPI-17Abstract
Aortic smooth muscle cells (ASMCs) form the tunica media of the aortic wall and play a central role in maintaining arterial compliance and blood pressure. Their contraction is enhanced by intracellular Ca²⁺ signals, activation of myosin light chain kinase (MLCK) via the calcium–calmodulin complex, and the RhoA/ROCK and PKC/CPI-17 pathways, resulting in the formation of actin–myosin junctions and increased wall tension. Relaxation occurs through the activation of cGMP/PKG and β₂-adrenoceptor–cAMP/PKA pathways by nitric oxide (NO) synthesized by endothelial cells, which leads to a decrease in Ca²⁺ concentration and activation of myosin light chain phosphatase (MLCP).
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Vascular Smooth Muscle Cell Signaling Mechanisms for Contraction and Relaxation. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC2704475/
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