AORTA SILLIQ TOLALI MUSKUL HUJAYRALARINING QISQARISHI VA BO‘SHASHISHI MEXANIZMLARI

Mualliflar

  • Jo‘raboyev Shaxriyor Kokand Universiteti Andijon filiali
  • Ikramova Dilnozaxon Kokand Universiteti Andijon filiali

Kalit so‘zlar:

aorta, silliq tolali muskul hujayralari, tunica media, Ca²⁺/kalmudulin/MLCK, RhoA/ROCK, PKC/CPI-17

Abstrak

Aorta silliq tolali muskul hujayralari (STMHU) aorta devorining tunica media
qavatini tashkil etib, arterial moslashuvchanlik va qon bosimini barqaror saqlashda markaziy rol
o‘ynaydi. Ularning qisqarishi hujayra ichidagi Ca²⁺ signallari, kalsiy–kalmudulin kompleksi orqali
myozin yengil zanjir kinazani (MLCK) faollashtirish, shuningdek RhoA/ROCK va PKC/CPI-17
yo‘llari orqali kuchaytiriladi, natijada aktin–miozin kesishmalari hosil bo‘lib, devor tarangligi
oshadi. Bo‘shashish esa endoteliy hujayralaridan sintezlangan azot oksidi (NO) orqali cGMP/PKG
hamda β₂-adrenoseptor–cAMP/PKA yo‘llarini ishga solishi natijasida Ca²⁺ konsentratsiyasi
pasayishi va myozin yengil zanjir fosfataza (MLCP) faollashuvi orqali yuzaga keladi.

References

Aorta. Wikipedia. https://en.wikipedia.org/wiki/Aorta

Tunica media. Wikipedia. https://en.wikipedia.org/wiki/Tunica_media

Smooth muscle. Wikipedia. https://en.wikipedia.org/wiki/Smooth_muscle

Mechanisms of Vascular Smooth Muscle Contraction and the Basis of Relaxation. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC4819215/

RhoA/Rho-Kinase: Pathophysiological and Therapeutic Implications. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC5599165/

Complex interactions of NO/cGMP/PKG systems on Ca2+ signaling. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC2806127/

Vascular Smooth Muscle Cell Signaling Mechanisms for Contraction and Relaxation. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC2704475/

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2025-06-16

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Jild 2 Nomeri 4.5 (2025): FARMASEVTIKA, BIOTEXNOLOGIYA VA BIOTIBBIYOTDA ZAMONAVIY TADQIQOTLAR VA ILMIY YANGILIKLAR” mavzusidagi xalqaro ilmiy-amaliy konferensiya Andijon. 23-24 aprel 2025-yil

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Copyright (c) 2025 Jo‘raboyev Shaxriyor, Ikramova Dilnozaxon

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How to Cite

AORTA SILLIQ TOLALI MUSKUL HUJAYRALARINING QISQARISHI VA BO‘SHASHISHI MEXANIZMLARI. (2025). Universal Xalqaro Ilmiy Jurnal, 2(4.5), 313-315. https://universaljurnal.uz/index.php/jurnal/article/view/2404