ВЛИЯНИЕ 2,3-ДИГИДРОКСИГЛУТАМИНОВОЙ КИСЛОТЫ НА Сa2+-ЗАВИСИМЫЕ МЕГАПОРЫ В МИТОХОНДРИЯХ

Abstract

The mPTP is involved in the regulation of physiological and pathological cellular processes. The opening of the mPTP is reversible to some extent, and the pore can be either temporarily or permanently open [Bonora M. 2020]. Low permeability is associated with the temporary opening of the mPTP, which allows the redistribution of H
+
and Ca
2+
ions across the inner mitochondrial membrane. The short-term, physiological opening and closing of the low permeability pore of the mPTP and the release of signaling molecules (Ca
2+
ions and mitochondrial KFSh) into the cytosol [Boyman L., 2019; Cosme P., 2020]. This process is associated with a short-term depolarization of the mitochondrial membrane potential, which leads to activation of the respiratory chain, acceleration of electron flow and, as a result, a decrease in the production of phosphodiesterase. It is associated with the constant opening of the high-permeability pore, which leads to complete and permanent mitochondrial depolarization and redistribution of ions and solutes across the inner mitochondrial membrane. Damage occurs to the supracomplexes of the respiratory chain [Zhang S. 2017], which leads to a deterioration in electron flow, especially to an increase in the production of phosphodiesterase through complex I.