2,3-DIGIDROKSI - GLUTAMAT KISLOTASINING MITOXONDRIYALARDAGI Сa2+-BOG'LIQ MEGAPORAGA TA'SIRI
Kalit so‘zlar:
mPTP, Ca 2+ ionlari, pH, mitoxondriya, depolyarizatsiyaAbstrak
mPTP fiziologik va patologik hujayra jarayonlarini boshqarishda ishtirok etadi
mPTPning ochilishi ma’lum darajada teskari bo‘lib, pora vaqtincha yoki doimiy ravishda ochilishi
mumkin [Bonora M. 2020]. Past o‘tkazuvchanlik mPTPning vaqtincha ochilishi bilan bog‘liq
bo‘lib, mitoxondriyalar ichki membranasi bo‘ylab H
+
va Ca
2+
ionlarini qayta taqsimlanishini
imkonini beradi. mPTP ning past o‘tkazuvchan poraning qisqa muddatli, fiziologik ochilishi va
yopilishi hamda sitozolga signal molekulalarining (Ca
2+
ionlari va mitoxondriyalar KFSh) chiqishi
bilan bog‘liq [Boyman L., 2019; Cosme P., 2020]. Bu jarayon mitoxondriyalar membrana
potensialining qisqa muddatli depolarizatsiyasi bilan bog‘liq bo‘lib, nafas olish zanjirining
faollashishi, elektronlar oqimining tezlashishi va buning natijasida KFSh larining pasayishiga olib
keladi. Yuqori o‘tkazuvchan poraning doimiy ochilishi bilan bog‘liq bo‘lib, to‘liq va doimiy
mitoxondriya depolyarizatsiyaga va mitoxondriya ichki membranasi bo‘ylab ionlar va
eritmalarning qayta taqsimlanishiga olib keladi. Nafas olish zanjirining suprakomplekslariga zarar
yetkaziladi [Jang S. 2017], bu elektronlar oqimining yomonlashishiga, ayniqsa I kompleks orqali
KFSh ishlab chiqarishni ko‘payishiga olib keladi.
References
Bonora M., Patergnani S., Ramaccini D. et al. Physiopathology of the permeability transition pore: molecular mechanisms in human pathology // Biomolecules. – 2020. – V. 10: (998). – P. 1-26.
Boyman L., Coleman A.K., Zhao G. et al. Dynamics of the mitochondrial permeability transition pore: Transient and permanent opening events // Arch. Biochem. Biophys. – 2019. – V. 666: – P. 31–39.
Cosme P., Rodríguez A.B., Yespino J., Garrido M. Plant phenolics: Bioavailability as a key determinant of their potential health-promoting applications // Antioxidants – 2020. – V.9 (12). – P. 1-20.
Jang S., Lewis T.S., Powers C., Khuchua Z., Baines C.P., Wipf P., Javadov S. Elucidating mitochondrial electron transport chain supercomplexes in the heart during ischemia–reperfusion // Antioxid. Redox Signal. – 2017. – V.27: – P. 57-69.
He L., Lemasters J.J. Heat shock suppresses the permeability transition in rat liver mitochondria // J. Biol. Chem. – 2003. – V. 278(19). – P. 16755-16760.
Schneider W.C., Hogeboom G.H. Cytochemical studies of mammalion tissues: the isolation of cell components by differential centrifugation // Cancer. Res. – 1951. – 11. – P. 1-22.
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