THE ROLE OF SELENIUM IN PATHOGENESIS AND TREATMENT OF THYROID DISEASES
Keywords:
селен, аутоиммунный тиреоидит, болезнь Грейвса, гипотиреоз, антиоксидантная защита, тиреоидные гормоны.Abstract
This review examines the role of selenium in the pathogenesis and treatment of thyroid diseases, including autoimmune thyroiditis, Graves' disease, hypothyroidism, and endemic goiter. Selenium is involved in the functioning of antioxidant enzymes and the metabolism of thyroid hormones, protecting thyrocytes from oxidative stress and regulating the immune response. Modern literature data are analyzed with
differentiation of clinical effects by levels of evidence (A-C).
It has been established that in autoimmune thyroiditis, selenium intake can reduce the level of antibodies to thyroid peroxidase and improve the clinical condition, while the effectiveness
in Graves' disease and in combination therapy with iodine requires further
confirmation. The need for an individual approach to the appointment of selenium based on a laboratory assessment of its level in the body is emphasized. The findings of the review may serve as a basis for optimizing the management strategy for patients with thyroid disorders.
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