INDUCATION OF DIABETES MODEL IN RATS BY LEAD INTOXICATION AND HIGH FAT DIET
Keywords:
rat, lead, heavy metals, bile, organism, toxic substances, xenobiotics, type 2 diabetes, environment, blood, glucose, liver, glycogenAbstract
Pathological conditions resulting from the accumulation of heavy metals that enter the body directly or indirectly are of particular interest. In this study, male white mongrel rats weighing 210-220 grams were given water containing 0.05 mg/kg lead salt for 28 weeks and fed a high-fat diet during this time. The amount of glucose in the blood of the animals was checked on the 7th, 14th, 21st and 28th weeks of the experiment. According to his data, it was found that the amount of blood glucose increased by 39.1 per cent in 7 weeks, by 60.7 per cent in 14 weeks, and by almost 2.5 times in 21 weeks. It was observed that by 28 weeks the blood glucose level increased almost 3.5 times, with the index in the control group being 5.2 mmol/l and in the experimental group - 18.2 mmol/l.
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Copyright (c) 2025 Karimova Irodakhon Ibrohimjonovna, Ergashev Nurali Agzamovich, Nazarova Dilbar Tolmasovna, Mavlonbekov Muslimbek Turdikamolovich
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