HEART MITOCHONDRIA ARE HIGHER IN AN EXPERIMENTAL ISCHEMIA MODEL SOFOROFLAVONOZIDE AND NARCISSIN IN THE TRANSMISSION PORGE EFFECT OF FLAVONOIDS

Authors

  • Pozilov M.K Pozilov M.K National University of Uzbekistan named after Mirzo Ulugbek
  • Abduraxmоnova M.J. Abduraxmоnova M.J. Andijan State Pedagogical Institute
  • Nishanbayev S.Z Nishanbayev S.Z Namangan State University
  • Mirzaolimov E.I. Mirzaolimov E.I. Namangan State University

Keywords:

Cardiomyocyte, derailment, active, death, mitochondria

Abstract

Currently, in the conditions of ischemia, the intensity of peroxide oxidation of
lipids of the heart mitochondria membrane increases, ATF synthesis decreases, antioxidant
enzyme activities change, and mPTP permeability increases [3]. However, in the conditions of
experimental ischemia, SFL isolated from the plant Crocus sativus L. belonging to the family
Iridaceae and Alhagi canescens (Regel) belonging to the family Fabaceae (Leguminosae) B.
Keller & Shap. The effects of flavonoids isolated from the plant Narcissin have not been
studied.

References

Gayibov U., Gayibova S.N., Pozilov M.K., Tuxtaeva F.Sh., Yusupova U.R., Djabbarova Gulchehra M.-K., Mamatova Z.A., Ergashev N.A., Aripov T.F. Influence of quercetin and dihydroquercetin on some functional parameters of rat liver mitochondria // JMBFS -2021. - V.11 (1). – P. 1-7.

Ong S-B., Samangouei P., Kalkhoran S. B., Hausenloy D.J. The mitochondrial permeability transition pore and its role in myocardial ischemia reperfusion injury // Journal of microbiology, biotechnology and food scienc Journal of Molecular and Cellular Cardiology – 2015. - V.78 –P. 23-34.

Hurst S., Gonnot F., Dia M., Da Silva C.C., Gomez L., Sheu S-S. Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion // Cell Death and Disease – 2020 - V.661. - P. 1-12.

Нишанбаев С.З., Шамьянов И.Д., Арипова С.Ф., Сагдуллаев Ш.Ш. Метаболиты растений рода Алъаги / Монография. – 2020. – С. 204.

Ахмеров Р.Н. Размельчитель ткани (комбинированный гомогенизатор) с резьбовым ножевым блоком и тканеподающим устройством // Узб. биол. журн. – 1979. – №5. – С. 71-72.

Егорова М.В., Афанасьев С.А. Регуляторная роль свободных жирных кислот в поддержании мембранного гомеостаза митохондрий сердца при экспериментальной ишемии миокарда // Бюллетень сибирской медицины – 2012. - №3. – P. 31-38.

Downloads

Published

2024-06-24

Issue

Vol. 1 No. 4 (2024): Scientific and practical republican on the topic "Actual problems, innovations and prospects of the sciences of human physiology and life activity safety" Proceedings of the conference

Section

Articles

License

Copyright (c) 2024 Pozilov M.K, Abduraxmоnova M.J., Nishanbayev S.Z, Mirzaolimov E.I.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

HEART MITOCHONDRIA ARE HIGHER IN AN EXPERIMENTAL ISCHEMIA MODEL SOFOROFLAVONOZIDE AND NARCISSIN IN THE TRANSMISSION PORGE EFFECT OF FLAVONOIDS. (2024). Universal International Scientific Journal, 1(4), 102-104. https://universaljurnal.uz/index.php/jurnal/article/view/461