ALTSGEYMER KASALLIGI : RIVOJLANISH SABABLARI VA DAVOLASH IMKONIYATLARINI ILMIY TAHLILI
Kalit so‘zlar:
Tau proteini, Neyrodegeneratsiya, Genetik omillar, Neyroinflamatsiya, Kognitiv buzilishAbstrak
Ushbu maqolada Altsgeymer kasalligi va uning rivojlanish sabablari,
patogenezi hamda davolash imkoniyatlari ilmiy tahlil qilinadi. Kasallik asosan beta-amiloid
blyashkalari, tau proteinining patologik yig‘ilishi, neyroinflamatsiya va genetik omillar natijasida
yuzaga keladi. APOE4, PSEN1 va PSEN2 genlari ushbu kasallik xavfini oshiruvchi asosiy omillar
hisoblanadi. Profilaktik choralar, jumladan O‘rta yer dengizi dietasi, jismoniy va aqliy faollik,
yaxshi uyqu gigiyenasi kasallik xavfini kamaytirishga yordam beradi. Kelajakda gen terapiyasi va
ilg‘or biotexnologik yondashuvlar asosida samarali davolash strategiyalari ishlab chiqilishi
kutilmoqda.
References
Alzheimer's Association. (2024). 2024 Alzheimer’s Disease Facts and Figures. Alzheimer's & Dementia, 20(3), 487-529. https://www.alz.org
Selkoe, D. J., & Hardy, J. (2016). The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO Molecular Medicine, 8(6), 595-608. https://doi.org/10.15252/emmm.201606210
Jack, C. R., et al. (2018). NIA-AA research framework: Toward a biological definition of Alzheimer’s disease. Alzheimer's & Dementia, 14(4), 535-562. https://doi.org/10.1016/j.jalz.2018.02.018
De Strooper, B., & Karran, E. (2016). The Cellular Phase of Alzheimer's Disease. Cell, 164(4), 603-615. https://doi.org/10.1016/j.cell.2016.01.002
Cummings, J., et al. (2023). Advances in Alzheimer’s disease drug development: 2023 pipeline update. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 9(1), e12391. https://doi.org/10.1002/trc2.12391
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