SARATON IMMUNITETINING NEYROPSIXOLOGIK VA NUTRITSIONAL MODULATORLARI: IMMUNO-ONKOLOGIYADA KO'P PERSPEKTİVA.
Kalit so‘zlar:
Immuno-oncology, chronic stress, tumor immunity, neuroimmunology, CAR-T therapy, GMOs, gut microbiota, psychological stress, immune suppression, cancer microenvironmentAbstrak
Immuno-onkologiya, saraton kasalligini tadqiq qilishning yangi sohasi, immunitet tizimining xavfli o'smalarni aniqlash va yo'q qilish qobiliyatidan foydalanadi. Immunitetni nazorat qilish punkti ingibitorlari va CAR T-hujayra terapiyasi kabi istiqbolli yutuqlarga qaramay, davolash samaradorligi bemorlar orasida keng farq qiladi. Rivojlanayotgan tadqiqotlar shuni ko'rsatadiki, mezbonning psixologik holati va parhezga ta'sir qilish, xususan, genetik va kimyoviy jihatdan o'zgartirilgan oziq-ovqatlar immunitetni o'zgartirishi, o'smaning rivojlanishiga ta'sir qilishi va davolash natijalariga vositachilik qilishi mumkin. Ushbu maqolada o'sma immunitetiga neyropsikologik va parhez ta'siri bo'yicha joriy adabiyotlarning keng qamrovli akademik sintezi keltirilgan. Surunkali stressni, ichak mikrobiotasini o'zgartirishni va immunitetni bostirishni o'sma mikro muhiti bilan bog'laydigan saratonning ko'p o'lchovli "neyro-psixo-immunologik modeli" taklif etiladi. Ushbu fanlararo tahlil paradigma o'zgarishini ko'rsatadi: saraton nafaqat genetik yoki hujayrali hodisa, balki atrof-muhit va xulq-atvor omillari ta'sirida integratsiyalashgan tizimli kasallikdir. Bunday tushunish zamonaviy onkologiyada ko'proq shaxsiylashtirilgan, profilaktika va yaxlit terapevtik strategiyalarga olib kelishi mumkin
Yuklashlar
References
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