OSHQOZONDA UGLEVODLARNING DASTLABKI PARCHALANISHINING OQSIL GIDROLIZIGA TA'SIRI
Kalit so‘zlar:
so'lak amilazasi, pepsin, uglevodlar gidrolizi, oqsil hazmi, dekstrinlar, maltoza, oshqozon-ichak fermentlari, klinik tadqiqot, biokimyoAbstrak
Maqolada og'iz bo'shlig'ida so'lak alfa-amilazasi (KF 3.2.1.1) ta'sirida uglevodlarning dastlabki parchalanishi va bu jarayonning oshqozondagi oqsil gidrolizi samaradorligiga ta'siri o'rganilgan. Tadqiqot 32 nafar 18–25 yoshli sog'lom volontyorlarda klinik metod asosida olib borildi. Pepsin (KF 3.4.23.1) fermentining proteoliytik faolligi spektrofotometrik usulda Anson modifikatsiyasi yordamida o'lchandi. Olingan natijalar ko'rsatdiki, so'lak amilazasi ta'sirida hosil bo'lgan dekstrinlar va maltozaning oshqozonga tushishi pepsin faolligini o'rtacha 15,4% ga (p<0,05) oshiradi. Mazkur o'zaro ta'sir mexanizmi hazm jarayonining yaxlitligini ta'minlovchi muhim biokimyoviy bog'lanishni ifoda etadi va dietologiya, gastroenterologiya hamda parhez ovqatlanish sohalarida amaliy ahamiyatga ega.
References
Akhmedov M., Karimov R. Biokimyo asoslari: Darslik. — Toshkent: O'zbekiston, 2021. — 412 b.
Berg J.M., Tymoczko J.L., Stryer L. Biochemistry. — 9th edition. — New York: W.H. Freeman, 2019. — 1224 p.
Butterworth P.J., Warren F.J., Ellis P.R. Human α-amylase and starch digestion: An interesting marriage // Starch-Stärke. — 2011. — Vol. 63, № 7. — Pp. 395–405.
Carpenter G.H. The secretion, components, and properties of saliva // Annual Review of Food Science and Technology. — 2013. — Vol. 4. — Pp. 267–276.
Fried M., Abramson S., Meyer J.H. Passage of salivary amylase through the stomach in humans // Digestive Diseases and Sciences. — 1987. — Vol. 32, № 10. — Pp. 1097–1103.
Goodman B.E. Insights into digestion and absorption of major nutrients in humans // Advances in Physiology Education. — 2010. — Vol. 34, № 2. — Pp. 44–53.
Karimov A.X., Yusupova D.B. Inson fiziologiyasi: O'quv qo'llanma. — Toshkent: Tibbiyot, 2020. — 358 b.
Mandel A.L., Breslin P.A.S. High endogenous salivary amylase activity is associated with improved glycemic homeostasis following starch ingestion in adults // Journal of Nutrition. — 2012. — Vol. 142, № 5. — Pp. 853–858.
Mursalov Sh.M., To'lqinov A.B. Biokimyo. — Toshkent: Fan, 2019. — 392 b.
Nelson D.L., Cox M.M. Lehninger Principles of Biochemistry. — 7th edition. — New York: W.H. Freeman, 2017. — 1328 p.
Pedersen A.M.L., Sørensen C.E., Proctor G.B., et al. Salivary secretion in health and disease // Journal of Oral Rehabilitation. — 2018. — Vol. 45, № 9. — Pp. 730–746.
Piper D.W., Fenton B.H. pH stability and activity curves of pepsin // Gut. — 1965. — Vol. 6. — Pp. 506–508.
Rasulov M.M., Xayrullayev S.X. Ozuqalanish biokimyosi. — Toshkent: O'zMU, 2022. — 286 b.
Salimov B., Karimova M. Hazm tizimining biokimyoviy asoslari. — Samarqand: SamDU, 2021. — 218 b.
Whitcomb D.C., Lowe M.E. Human pancreatic digestive enzymes // Digestive Diseases and Sciences. — 2007. — Vol. 52, № 1. — Pp. 1–17.
(+998)90 142-39-38
Andijon viloyati, Marhamat tumani, Qashqar ko’chasi 189-uy