MITOXONDRIYALARDA OKSIDATIV FOSFORILLANISHNING HUJAYRALARNING yashovchanligidagi roli.

Mualliflar

  • Абдурашидов Абдумажид Алишер угли Andijon davlat universiteti
  • Туйчиева Дилфуза Сидикжановна Andijon davlat universiteti

Kalit so‘zlar:

Oksidlanishli fosforlanish, mitoxondriyalar, hujayra energiyasi, sirkadiyalik ritmlar, qarish, biologik soat.

Abstrak

Ish hujayra hayotiyligini saqlashda oksidlovchi fosforlanishning (OP) rolini o'rganishga bag'ishlangan. Mitoxondriyadagi OP samaradorligini oshirish hujayra hayotini uzaytirishga va sirkadiyalik ritmlarni barqarorlashtirishga yordam berishi mumkinligi haqidagi gipoteza taklif etiladi. Energiya almashinuvini "soat" genlarining ifodasi va qarish bilan bog'laydigan mexanizmlar muhokama qilinadi. Yoshga bog'liq va metabolik kasalliklarni davolashda potentsial maqsad sifatida mitoxondriyal metabolizmning ahamiyati ta'kidlangan.

References

López-Otín C., Blasco M.A., Partridge L., Serrano M., Kroemer G. The hallmarks of aging // Cell. - 2013. - Vol. 153(6). - P. 1194-1217.

DOI: 10.1016/j.cell.2013.05.039

García-Ruiz C., Fernández-Checa J.C. Mitochondrial oxidative stress and aging //Ageing Research Reviews. - 2025. - Vol. 88. DOI: 10.1016/j.arr.2025.101068

Jacobi D., Liu S., Burkewitz K., et al. Hepatic Bmal1 regulates rhythmic mitochondrial dynamics and promotes metabolic fitness // Cell Metabolism. - 2015. - Vol. 22(4). - P. 709-720. DOI: 10.1016/j.cmet.2015.08.006

Peek C.B., Affinati A.H., Ramsey K.M., et al. Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice // Science. - 2013. - Vol. 342(6158). - P. 1243417. DOI: 10.1126/science.1243417

Wang Y., Hekimi S. Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis // Nature Communications. 2016. Vol. 7. — Article 11771. DOI: 10.1038/ncomms11771

Zhang Y., Liu T., Zhou X. Mitochondrial dysfunction in cardiovascular diseases: mechanisms and therapy // Signal Transduction and Targeted Therapy. - 2024. - Vol. 9, Article 132. DOI: 10.1038/s41392-024-01839-8

Бабун Н. А., Ковальчук В. А. Сердечная недостаточность и митохондриальная дисфункция // Acta Biomedica Scientifica. - 2022. - Т. 7, № 2. - С. 50–58.DOI: 10.12737/ABM.2022.29.

Киселёв Д. И. Нефосфорилирующее окисление в митохондриях и его регуляция // Биохимия. — 2020. — Т. 85, № 12. — С. 1549–1572.

DOI: 10.31857/S032097252012009X.

Свободные от кристы митохондрии — хит сезона // БиоМолекула. — 2023. — URL: https://biomolecula.ru/articles/svobodnye-ot-kristy-mitokhondrii-khit-sezona (дата обращения: 14.05.2025).

Zhang Y., Liu T., Zhou X. Mitochondrial dysfunction in cardiovascular diseases: mechanisms and therapy // Signal Transduction and Targeted Therapy. — 2024. — Vol. 9, Article 132.

DOI: 10.1038/s41392-024-01839-8.

Patel A., Huang M. Oxidative phosphorylation and its emerging role in stem cell differentiation // Cell. — 2025. — Vol. 188, Issue 9. — P. 1752–1767.

DOI: 10.1016/j.cell.2024.04.012.

García-Ruiz C., Fernández-Checa J.C. Mitochondrial oxidative stress and aging//Ageing Research Reviews. 2025. Vol. 88.

DOI: 10.1016/j.arr.2025.101068.

Petrovic M., Altmann M. Time to update textbooks on electron transport chain in mitochondria // Phys.org. — 2025. — URL: https://phys.org/news/2025-02-textbooks-electron-chain-mitochondria.html (дата обращения: 14.05.2025).

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2025-06-23

How to Cite

MITOXONDRIYALARDA OKSIDATIV FOSFORILLANISHNING HUJAYRALARNING yashovchanligidagi roli. (2025). Universal Xalqaro Ilmiy Jurnal, 2(4.4), 307-309. https://universaljurnal.uz/index.php/jurnal/article/view/2818