MITOXONDRIYALARDA OKSIDATIV FOSFORILLANISHNING HUJAYRALARNING yashovchanligidagi roli.
Kalit so‘zlar:
Oksidlanishli fosforlanish, mitoxondriyalar, hujayra energiyasi, sirkadiyalik ritmlar, qarish, biologik soat.Abstrak
Ish hujayra hayotiyligini saqlashda oksidlovchi fosforlanishning (OP) rolini o'rganishga bag'ishlangan. Mitoxondriyadagi OP samaradorligini oshirish hujayra hayotini uzaytirishga va sirkadiyalik ritmlarni barqarorlashtirishga yordam berishi mumkinligi haqidagi gipoteza taklif etiladi. Energiya almashinuvini "soat" genlarining ifodasi va qarish bilan bog'laydigan mexanizmlar muhokama qilinadi. Yoshga bog'liq va metabolik kasalliklarni davolashda potentsial maqsad sifatida mitoxondriyal metabolizmning ahamiyati ta'kidlangan.
References
López-Otín C., Blasco M.A., Partridge L., Serrano M., Kroemer G. The hallmarks of aging // Cell. - 2013. - Vol. 153(6). - P. 1194-1217.
DOI: 10.1016/j.cell.2013.05.039
García-Ruiz C., Fernández-Checa J.C. Mitochondrial oxidative stress and aging //Ageing Research Reviews. - 2025. - Vol. 88. DOI: 10.1016/j.arr.2025.101068
Jacobi D., Liu S., Burkewitz K., et al. Hepatic Bmal1 regulates rhythmic mitochondrial dynamics and promotes metabolic fitness // Cell Metabolism. - 2015. - Vol. 22(4). - P. 709-720. DOI: 10.1016/j.cmet.2015.08.006
Peek C.B., Affinati A.H., Ramsey K.M., et al. Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice // Science. - 2013. - Vol. 342(6158). - P. 1243417. DOI: 10.1126/science.1243417
Wang Y., Hekimi S. Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis // Nature Communications. 2016. Vol. 7. — Article 11771. DOI: 10.1038/ncomms11771
Zhang Y., Liu T., Zhou X. Mitochondrial dysfunction in cardiovascular diseases: mechanisms and therapy // Signal Transduction and Targeted Therapy. - 2024. - Vol. 9, Article 132. DOI: 10.1038/s41392-024-01839-8
Бабун Н. А., Ковальчук В. А. Сердечная недостаточность и митохондриальная дисфункция // Acta Biomedica Scientifica. - 2022. - Т. 7, № 2. - С. 50–58.DOI: 10.12737/ABM.2022.29.
Киселёв Д. И. Нефосфорилирующее окисление в митохондриях и его регуляция // Биохимия. — 2020. — Т. 85, № 12. — С. 1549–1572.
DOI: 10.31857/S032097252012009X.
Свободные от кристы митохондрии — хит сезона // БиоМолекула. — 2023. — URL: https://biomolecula.ru/articles/svobodnye-ot-kristy-mitokhondrii-khit-sezona (дата обращения: 14.05.2025).
Zhang Y., Liu T., Zhou X. Mitochondrial dysfunction in cardiovascular diseases: mechanisms and therapy // Signal Transduction and Targeted Therapy. — 2024. — Vol. 9, Article 132.
DOI: 10.1038/s41392-024-01839-8.
Patel A., Huang M. Oxidative phosphorylation and its emerging role in stem cell differentiation // Cell. — 2025. — Vol. 188, Issue 9. — P. 1752–1767.
DOI: 10.1016/j.cell.2024.04.012.
García-Ruiz C., Fernández-Checa J.C. Mitochondrial oxidative stress and aging//Ageing Research Reviews. 2025. Vol. 88.
DOI: 10.1016/j.arr.2025.101068.
Petrovic M., Altmann M. Time to update textbooks on electron transport chain in mitochondria // Phys.org. — 2025. — URL: https://phys.org/news/2025-02-textbooks-electron-chain-mitochondria.html (дата обращения: 14.05.2025).
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