NITRIT VA NITRATLAR INTOKSIKATSIYASINING INSON ORGANIZMIGA TA’SIRI
Kalit so‘zlar:
Jahon Sog‘liqni saqlash tashkiloti, Amerikalik, meva, don, suvAbstrak
Nitrit toksikligining asosiy mexanizmi temirning oksidlanishidir. YA’ni
gemoglobin tarkibidagi temir (Fe2+) ni temir (Fe3+) valentlik holatiga o‘tib metemoglobinni
hosil qilishidadir. Adabiyotlardan ma’lumki, metemoglobin hosil bo‘lishi natijasida inson
to‘qimalari va hujayralariga kislorod yetib borish jarayonida buzilishlar kuzatiladi
Natijada, organizmda turli patologik holatlarning rivojlanishi uchun imkoniyat
yaratiladi. Aytishimiz mumkinki, organizmni niritlar bilan zaharlanishi qon tarkibidagi
metgemoglabin ulushiga bog‘liq. So‘ngi yillarda olib borilgan ilmiy tadqiqotlar inson saratoni
etiologiyasida azot oksidining qonda ko‘payishishini isbotlagan.
References
Жиляев В.А., Басов А.С., Полехина Н.Н. Влияние нитратов и нитритов на организм человека // Международный студенческий научный вестник. – 2022. – № 5.
Bahadoran, Z., Ghasemi A.., Mirmiran P .// Beneficial effects of inorganic nitrate/nitrite in type 2 diabetes and its complications.// Nutr Metab 12, 16, 2015.
Bahadoran, Z., Ghasemi A.., Mirmiran P .// Beneficial effects of inorganic nitrate/nitrite in type 2 diabetes and its complications.// Nutr Metab 12, 16, 2015.
Karwowska M., Anna Kononiuk A. Nitrites in Food—Risk for Nitrosative Stress and Benefits // Antioxidants 2020. 9, 241.
Keller R. M., Beaver, Laura PhD, MS; Prater, M. Catherine; Hord, N orman G. Dietary Nitrate and Nitrite Concentrations in Food Patterns and Dietary Supplements//Nutrition Today, 2020. Vol. 55, No. 5, 218-226.
Mensinga T.T., Speijers G.J.A., Meulenbelt J. (2003) Health implications of exposure to environmental nitrogenous compounds, Toxicol. Rev. 22, 41–51.
Michaud D.S., Mysliwiec P.A., Aldoori W., Willett W.C., Giovannucci E. (2004) Peptic Ulcer Disease and the Risk of Bladder Cancer in a Prospective Study of Male Health Professionals, Cancer Epidem. Biomar. 13, 250–25.
Portnov А. Poisoning with nitrates and nitrites URL: https://m.iliveok.com/health/poisoning-nitrates-and-nitrites_128990i15958.html ( Дата обращения: 4.06.2022
Shah I., Petroczi A., James R.A., Naughton D. P Determination of Nitrate and Nitrite Content of Dietary Supplements Using Ion Chromatography // Journal of Analytical & Bioanalytical Techniques, 2013.
Szaleczky E., Pronai L., Nakazawa H., Tulassay Z. (2000) Evidence of in vivo peroxynitrite formation in patients with colorectal carcinoma, higher plasma nitrate/nitrite levels, and lower protection against oxygen free radicals, J. Clin. Gastroenterol. 30, 47–51.
Turkdogan M.K., Testereci H., Akman N., Kahraman T., Kara K., Tuncer I., Uygan I. (2003) Dietary nitrate and nitrite levels in an endemic upper gastrointestinal (esophageal and gastric) cancer region of Turkey, Turk. J. Gastroenterol. 14, 50–53.
Нитраты и нитриты также могут использоваться в качестве добавок в пищевых продуктах животного происхождения. Нитриты (нитрит натрия — E249, нитрит калия — E250) и нитраты (нитрат натрия — E251, нитрат калия — E252) разрешены в качестве пищевых добавок в Европейском Союзе в соответствии с Регламентом Комиссии (ЕС) № 1129/2011.
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