AYRIM GIDROLIZLANUVCHI TANINLARNING AORTA SILLIQ MUSKUL PREPARATIGA RELAKSANT TA‘SIRIDA SARKOPLAZMATIK RETIKULUM RIANODIN RETSEPTORINING ISHTIROKINI BAHOLASH
Kalit so‘zlar:
aorta silliq muskuli, gidrolizlanuvchi taninlar, vazorelaksant, ion kanallari, verapamilAbstrak
Silliq muskul hujayralari sarkoplazmatik retikulum (SR) Ca2+
-transport
tizimlari ya‘ni rianodin retseptori (RyR) va inozitol-1,4,5-trisfosfat retseptori (IP3R) hamda
Ca2+
-ATFaza (SERCA) asosan SMH lari Ca2+ gomeostazining regulyatsiyasida muhim
ahamiyat kasb etadi [1; 50-86-b.; 2; 266-286-b.]. SERCA faolligi orqali Ca2+ gomeostazida va
hujayra ichki [Ca]i konsentratsiyasini kamaytirishda ishtirok etadi. Shuningdek, SERCA orqali
Ca2+ ionlarining konsentratsiyasi kamaytiriladi va silliq muskul hujayralarining bo‘shashishiga
olib keladi [3; 84-93-b.]. IP3R retseptorlari - yoki rianodin retseptorlari (RyR) – SR dan
sitozolga Ca2+ ionlarining chiqishini ta‘minlovchi kanallar hisoblanadi [4; 2-9-b.]. Yuqorida
keltirilgan maʼluomotlarni hisobga olib, ushbu tadqiqot ishining maqsadi 1,2,6-tri-О-galloil-
-D-gulyukoza (GT-2) gidrolizlanuvchi taninining aorta silliq muskul preparatiga relaksant
ta‘sirida sarkoplazmatik retikulum rianodin retseptorining ishtrokinini baholash mexanizmini
oʼrganishdan iborat.
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