AYRIM GIDROLIZLANUVCHI TANINLARNING AORTA SILLIQ MUSKUL PREPARATIGA RELAKSANT TA‘SIRIDA SARKOPLAZMATIK RETIKULUM RIANODIN RETSEPTORINING ISHTIROKINI BAHOLASH

Mualliflar

  • Mutalipov Аzizbek Аbdullajon oʼgʼli Andijon davlat universiteti
  • Usmonov Poʼlat Bekmurodovich Andijon davlat universiteti
  • Zaynabiddinov Аnvar Erkinjonovich Andijon davlat universiteti
  • Mirzaolimova Gulhayo Jasurbek qizi Andijon davlat universiteti
  • Raximov Raxmatillo Nurallievich Andijon davlat universiteti

Kalit so‘zlar:

aorta silliq muskuli, gidrolizlanuvchi taninlar, vazorelaksant, ion kanallari, verapamil

Abstrak

Silliq muskul hujayralari sarkoplazmatik retikulum (SR) Ca2+
-transport
tizimlari ya‘ni rianodin retseptori (RyR) va inozitol-1,4,5-trisfosfat retseptori (IP3R) hamda
Ca2+
-ATFaza (SERCA) asosan SMH lari Ca2+ gomeostazining regulyatsiyasida muhim
ahamiyat kasb etadi [1; 50-86-b.; 2; 266-286-b.]. SERCA faolligi orqali Ca2+ gomeostazida va
hujayra ichki [Ca]i konsentratsiyasini kamaytirishda ishtirok etadi. Shuningdek, SERCA orqali
Ca2+ ionlarining konsentratsiyasi kamaytiriladi va silliq muskul hujayralarining bo‘shashishiga
olib keladi [3; 84-93-b.]. IP3R retseptorlari - yoki rianodin retseptorlari (RyR) – SR dan
sitozolga Ca2+ ionlarining chiqishini ta‘minlovchi kanallar hisoblanadi [4; 2-9-b.]. Yuqorida
keltirilgan maʼluomotlarni hisobga olib, ushbu tadqiqot ishining maqsadi 1,2,6-tri-О-galloil-
-D-gulyukoza (GT-2) gidrolizlanuvchi taninining aorta silliq muskul preparatiga relaksant
ta‘sirida sarkoplazmatik retikulum rianodin retseptorining ishtrokinini baholash mexanizmini
oʼrganishdan iborat.

References

Ghosh D., Syed A.U., Prada M.P., Nystoriak M.A., Santana L.F., Nieves-Cintrón M., Navedo M.F. Calcium Channels in Vascular Smooth Muscle // Advances in Pharmacology, Volume 78; 2017; p. 49-87

Yingzi Zhao, Paul M. Vanhoutte, Susan W.S. Leung. Vascular nitric oxide: Beyond eNOS // Journal of Pharmacological Sciences Volume 129, Issue 2, October 2015, Pages 83-94

Aihua Zhang, Hua Yu, Chunhong Liu, Chen Song. The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model // Nature Communications // (2020) 11: 922, p. 1-10

Yunusov L., Zaynabiddinov A., Adizov Sh., Khalilov E., Ahmedov F., Mutalipov A., Gayibov U. Vasorelaxant effect of Copsinine and N4-Iodine methylate alkaloids // Biotechnology & Microbiology. – Irvine, California, 2020. –V.15. – P.52-54.

Hoe S.–Z., Lee C.–N., Mok S.–L., Kamaruddin M.Y., Lam S.–K. Gynura procumbens Merr. decreases blood pressure in rats by vasodilatation via inhibition of calcium channels // Clinics. – 2011. – V.66(1). – P.143–150.

Yunusov L.S., Zaynabiddinov А.E., Аdizov Sh.M., Xalilov E.X., Аxmedov F.Yu., Mutalipov А.А. Vazorelaksantnoe deystvie alkaloidov kopsinin i N4-yod metilat kopsinina v zavisimosti ot ximicheskoy strukturы // Universum. Ximiya i biologiya. – Moskva, 2020. – № 11. – B. 17-23.

Parpiyeva, M., Tuychiyeva, D., & Numonjonov, M. (2020). EFFECTS OF HALOXYFOP-R-METHYLE AND INDOXACARB PESTICIDES ON THE STRUCTURE OF THE INTERNAL ORGANS OF RATS. Norwegian Journal of Development of the International Science, (45-2), 15-17.

Paridakhon, M., Dilfuza, T., Mashkhura, P., Dilnoza, B., & Ra’no, A. (2020). Some Indicators of Blood of Rats Poisoned with Pesticide Karate. International Journal of Multicultural and multireligious understanding, 7(7), 546-557.

Parpieva, M., Mirkhamidova, P., Pozilov, M., & Alimova, R. (2023). Effects of sophoroflavonoside and narcissin flavonoids on mitochondrial dysfunction and antioxidant enzyme activity in rat liver poisoned with galoxyfop-r-methyl pesticide. In E3S Web of Conferences (Vol. 421, p. 04008). EDP Sciences.

Туйчиева, Д., Муминова, Г., & Парпиева, М. (2018). Действие пестицидов на фосфолипидный состав митохондрий печени беременных крыс и их эмбрионов. Научный альманах, (3-2), 207-210.

Mashkhura, P., & Parida, M. (2020). Determination of residual pesticide in the liver of rats poisoned with indoxacarb pesticide. European Journal of Molecular and Clinical Medicine, 7(3), 4447-4505.

Туйчиева, Д., Мирхамидова, П., Бабаханова, Д., Парпиева, М., & Алимова, Р. (2020). ВЛИЯНИЕ ПЕСТИЦИДОВ НА АКТИВНОСТЬ НЕКОТОРЫХ ФЕРМЕНТОВ ПЕЧЕНИ КРЫС И ПУТИ ИХ КОРРЕКЦИИ. Norwegian Journal of Development of the International Science, (45-2), 8-14.

Parpieva, M. Z., & Tujchieva, D. S. (2021). Jigar, uning inson organizmidagi vazifalari va ahamiyati. Молодой ученый, (10), 234-237.

Dilfuza, T., Mashhura, P., Parida, M., Dilnoza, B., & Rano, A. (2020). Effect of pesticides on the content of cytochrome P-450 of the monooxygenase system and on the ultrastructure of hepatocytes in rat embryos. European Journal of Molecular and Clinical Medicine, 7(3), 2473-2483.

Mirkhamidova, P., Bobokhonova, D., Tuychieva, D., & Parpieva, M. (2020). Influence of karate on the activity of enzymes of the anti-oxidizing system of rat liver protection and ways of their correction. European Journal of Molecular and Clinical Medicine, 7(3), 3757-3765.

Parida, M., Komiljonovich, P. M. M., Javdatovna, P. M., Abdullaevna, S. G., & Abjapparovna, J. K. (2022). Determination of the amount of residual pesticides in the liver tissue of rats poisoning with haloxyphop-r-methyl and indosacarb pesticides. Journal of Pharmaceutical Negative Results, 738-745.

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2024-06-24

How to Cite

AYRIM GIDROLIZLANUVCHI TANINLARNING AORTA SILLIQ MUSKUL PREPARATIGA RELAKSANT TA‘SIRIDA SARKOPLAZMATIK RETIKULUM RIANODIN RETSEPTORINING ISHTIROKINI BAHOLASH. (2024). Universal Xalqaro Ilmiy Jurnal, 1(4), 111-113. https://universaljurnal.uz/index.php/jurnal/article/view/464