AORTIC SMOOTH MUSCLE OF SOME HYDROLYZABLE TANNINS SARCOPLASMATIC RETICULUME UNDER THE RELAXANT EFFECT OF THE DRUG EVALUATION OF RYANODINE RECEPTOR INVOLVEMENT
Keywords:
aortic smooth muscle, hydrolyzable tannins, vasorelaxant, ion channels, verapamilAbstract
Smooth muscle cell sarcoplasmic reticulum (SR) Ca
2+
-transport systems, i.e.
ryanodine receptor (RyR) and inositol-1,4,5-trisphosphate receptor (IP3R) and Ca
2+ -ATPase
(SERCA) mainly SMHs are important in regulation of Ca
2+ homeostasis becomes important
[1; pp. 50-86; 2; pp. 266-286]. Through its activity, SERCA is involved in Ca
2+ homeostasis
and reduction of intracellular [Ca
2+
]i concentration. Also, through SERCA, the concentration
of Ca
2+
ions is reduced and causes relaxation of smooth muscle cells [3; pp. 84-93]. IP3R
receptors - or ryanodine receptors (RyR) - are channels that ensure the release of Ca
2+
ions
from the SR to the cytosol [4; pp. 2-9]. Taking into account the above information, the purpose
of this study is to study the mechanism of sarcoplasmic reticulum ryanodine receptor activation
during the relaxant effect of 1,2,6-tri-O-galloyl--D-glucose (GT-2) hydrolyzable tannin on
aortic smooth muscle preparation. consists of
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Copyright (c) 2024 Mutalipov Аzizbek Аbdullajon oʼgʼli, Usmonov Poʼlat Bekmurodovich, Zaynabiddinov Аnvar Erkinjonovich, Mirzaolimova Gulhayo Jasurbek qizi, Raximov Raxmatillo Nurallievich
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