ISOLATION OF AMINO ACID-PEPTIDES FROM SECONDARY PRODUCTS AND THEIR BIOLOGICAL ACTIVITIES
Keywords:
amino acids, peptides, enzymatic hydrolysis, biological activity, secondary products, antioxidant, nutraceutical, bioactive substanceAbstract
This article analyzes the methods for isolating biologically active amino acids and peptides from protein-rich secondary products contained in food and industrial waste, as well as their biological activity properties. The study investigated the possibilities of obtaining amino acid-peptide complexes based on enzymatic hydrolysis, ultrafiltration and chromatographic separation technologies. The antioxidant, antibacterial, antihypertensive and immunomodulatory activities of the obtained peptides are described based on modern scientific sources. The prospects for the use of peptides isolated from secondary raw materials - fish bones, meat industry waste, whey and plant residues in the fields of medicine, pharmacy and nutraceuticals are highlighted. The results of the study show that the development of biological products with high added value from renewable raw materials is one of the most environmentally and economically effective directions.
References
Abraham LC, Zuena E, Perez-Ramirez B, Kaplan DL. Guide to collagen characterization for biomaterial studies. J Bomed Mater Res B Appl Biomater. 2008;87B(1):264–285. doi: 10.1002/jbm.b.31078.
AOAC (1990). In: Helrich K (ed) Official methods of analysis, 15th edn. Virginia
Bragulla HH, Homberger DG. Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia. J Anat. 2009;214:516–559. doi: 10.1111/j.1469-7580.2009.01066.x.
Cameron GJ, Wess TJ, Bosner RHC. Young’s modulus varies with differential orientation of keratin in feathers. J Struct Biol. 2003;143:118–123. doi: 10.1016/s1047-8477(03)00142-4.
Feroz, S.; Muhammad, N.; Ratnayake, J.; Dias, G. Keratin—Based Materials for Biomedical Applications. Bioact. Mater. 2020, 5, 496–509.
Sharma, S.; Kumar, A. Keratin as a Protein Biopolymer: Extraction from Waste Biomass and Applications; Sharma, S., Kumar, A., Eds.; Springer Series on Polymer and Composite Materials; Springer International Publishing: Cham, Switzerland, 2019; ISBN 978-3-030-02900-5.
Rajabi, M.; Ali, M.; McConnell, M.; Cabral, J. Keratinous Materials: Structures and Functions in Biomedical Applications. Mater. Sci. Eng. C 2020, 110, 110612.
Tesfaye, T.; Sithole, B.; Ramjugernath, D. Valorisation of Chicken Feathers: A Review on Recycling and Recovery Route—Current Status and Future Prospects. Clean Technol. Environ. Policy 2017, 19, 2363–2378.
Ansarullah RR, Kusno A, Baharuddin JN (2018) Utilization of waste of chicken feathers and waste of cardboard as the material of acoustic panel maker. IOP Conf Ser Earth Environ Sci 126:012036.
Bouhamed SBH, Kechaou N (2017) Kinetic study of sulphuric acid hydrolysis of protein feathers. Bioproc Biosyst Eng 40(5):715–721.
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