MITOXONDRIYA KASALLIKLARI VA HUJAYRA O‘LIMI
Kalit so‘zlar:
Miopatiya, Nevrologik, atrofiyasi, mioklonus, polineyropatiyaAbstrak
Maqolada hujayraning apoptoz yoki nekroz yo‘li bilan nobud bo‘lishida
mitoxondriya membranasi permeabilizatsiyasi muhim hisoblanadi. Hujayra o‘limiga olib
keluvchi signallarni ko‘pchiligini mitoxondriyaga keladi, masalan, bu jarayonda Bid va Bad
kabi Bcl-2 oqsillari ishtirok etadi.
Hujayra ichki signallarining yangidan hosil bo‘lishining turli yo‘llari kaspazalar
tizimining faollashuviga, sitozolda Ca2+, azot (II) oksid, amfipatik peptidlar va seramidlar
konsentratsiyasining oshishiga, bevosita yoki bilvosita holatda, mitoxondriya ion
o‘tkazuvchanligini o‘zgarishiga olib keladi
References
Murphy A.N., Fiskum G., Beal M.F. Mitochondria in Neurodegeneration: Bioenergetic Function in Cell Life and Death // Journal of Cerebral Blood Flow & Metabolism. – 1999. – V. 19. – P. 231-245
Treem W.R., Sokol R.J. Disorders of the mitochondria// Semin. Liver Dis. – 1998. – V.18. – P.237-253.
Hekimi S., Guarente L. Genetics and the specificity of the aging process // Science. – 2003. – V. 299. – P. 1351–1354.
Correa F., Soto V., Zazueta C. Mitochondrial permeability transition relevance for apoptotic triggering in the post-ischemic heart. // Int. J. Biochem. Cell Biol. – 2007. – V. 39. – P. 787-798.
Brookes P.S., Yoon Y., Robotham J.L., Anders M.W., Sheu Sh.Sh. Calcium, ATP, and ROS: a mitochondrial love-hate triangle// Am. J. Physiol. Cell. Physiol. – 2004. - V. 287. – P. C817-C833.
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